Search our team at AdventHealth Research Institute
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NCT04717414
ACE-536-MF-002: A Phase 3, Double-blind, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK Inhibitor Therapy and Who Require Red Blood Cell Transfusions (INDEPENDENCE)
This study is not currently enrolling.Associated Conditions: LymphomaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe main purpose of this study is to see if people with MPN-associated myelofibrosis that need blood transfusions will stop needing RBC transfusions or require less frequent RBC transfusions by taking...
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NCT04083599
GCT1042-01: A First-in-Human, Open-label, Dose-escalation Trial with Expansion Cohorts to Evaluate Safety and Anti-tumor Activity of GEN1042 in Subjects with Malignant Solid Tumors
This study is not currently enrolling.Associated Conditions: Malignant Pleural MesotheliomaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaGEN1042 is a bispecific antibody that crosslinks CD40 on antigen-presenting cells with 4-1BB on activated T cells, thereby inducing conditional stimulation of and co-stimulatory activity on both cell...
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NCT04419779
REVITALIZE-1: A Prospective randomized, double-blind, sham-controlled, multi-center pivotal study to evaluate the efficacy and safety of Duodenal Mucosal Resurfacing (DMR) using the Revita system in subjects with type 2 diabetes on insulin therapy.
This study is not currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of this study is to demonstrate the efficacy and safety of the Fractyl DMR Procedure using the Revita System compared to a sham.
To be enrolled in this study, you must meet...
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NCT05766813
A Randomized, Double-blind, Placebo-controlled Multicenter Study to Assess the Efficacy and Safety of Lenrispodun as Adjunctive Therapy in the Treatment of Patients with Motor Fluctuations due to Parkinson’s Disease”
This study is not currently enrolling.Associated Conditions: ParkinsonsResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this clinical research study is to look at an investigational study drug called lenrispodun. The study will investigate if lenrispodun can help to increase the time of good control of...
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NCT05754333
ASP5354: A Phase 3, Multicenter, Prospective, Randomized, Open-label Study for Intraoperative Ureter(s) Visualization When Using ASP5354 with Near-infrared Fluorescence (NIR-F) Imaging in Participants Undergoing Minimally Invasive and Open Abdominopelvic Surgeries.
This study is not currently enrolling.Research Area: Digestive Health and SurgeryResearch Location: Orlando, FloridaStudy Purpose: The biological father of your child is/was participating in a research study of an Investigational or experimental medicine that has not received approval from governmental regulatory...
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NCT05645692
B044157 A Phase II, Randomized, Multicenter, Open-Label, Controlled Study Of R07247669 Alone Or In Combination With Tiragolumab Versus Atezolizumab In Patients With Previously Untreated Locally Advanced Or Metastatic Urothelial Bladder Cancer Who Are Ineligible For Platinum-Containing Chemotherapy
This study is not currently enrolling.Associated Conditions: Urothelial CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, Florida -
NCT05047263
FIND-CKD: A randomized, double-blind, placebo-controlled, parallel-group, multicenter Phase 3 study to investigate the efficacy and safety of FInerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease.
This study is not currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: To determine the safety and efficacy of Finerenone along with standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease.
To be...
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Comparative effectiveness of Juntos Después del Cáncer (JDC) among Breast Cancer Survivors and their Intimate Partners
This study is not currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Orlando, Florida -
NCT05662865
CASINO: Low-Carbohydrate Diet and SGLT2-Inhibitor to Achieve Moderate Ketosis in Healthy Volunteers
This study is not currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaThe purpose of this study is to test the hypothesis that a low-carbohydrate diet combined with an SGLT2-inhibitor is sufficient to induce moderate ketosis in healthy volunteers.
To be enrolled in...
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NCT04865770
REMODEL: Renal Mode of Action of Semaglutide in Patients with Type 2 Diabetes and Chronic Kidney Disease.
This study is not currently enrolling.Associated Conditions: Diabetes-Care DeliveryResearch Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of this study is to determine how Semaglutide works in the kidneys in people with type 2 diabetes and chronic kidney disease.
To be enrolled in this study, you must meet...
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NCT05394519
REDEFINE2: Efficacy and safety of cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (CagriSema s.c. 2.4 mg/2.4 mg) once-weekly in participants with overweight or obesity and type 2 diabetes.
This study is not currently enrolling.Associated Conditions: Diabetes-Drug StudyResearch Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of the study is to investigate the efficacy and safety of two medications, cagrilintide and semaglutide. Cagrilintide in combination with semaglutide is currently under...
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NCT04223752
A Phase 1, open-label, non-comparative, multicenter clinical study to evaluate the safety, tolerability, and pharmacokinetics of ceftolozane/tazobactam (MK-7625A) in pediatric participants with nosocomial pneumonia
This study is not currently enrolling.Research Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaCeftolozane/tazobactam, also known as Zerbaxa, is a combination product, and is available by prescription for use in adults for the treatment of complicated urinary tract infections, including...