Search our team at AdventHealth Research Institute
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North American Pediatric Renal Trials Collaborative Studies (NAPRTCS)
This study is currently enrolling.Associated Conditions: TransplantResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaNAPRTCS is a research effort that was organized in 1987 by a group of physicians and surgeons committed to the success of pediatric renal transplant.
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NCT06819007
A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan with Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer” GOG 3112/ DSI-T-DXd ENHERTU (DO-01); DESTINY-Ovarian01 (DO-01)] DS8201-772
This study is not currently enrolling.Associated Conditions: Ovarian, Fallopian, or Primary Peritoneum CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis study consists of two parts: Part 1 (safety run-in) and Part 2 (randomized part [like the flip of a coin]). The purpose of Part 1 is to learn more about the safety and tolerability of the...
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NCT06639958
Risk-Based 6MP Adherence Enhancement Strategies in Children, Adolescent and Young Adults With ALL - A Pilot Study Study Sponsor: Children’s Oncology Group
This study is not currently enrolling.Research Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThis study is being done to answer the following question: Can we help children, adolescents and young adults with ALL to remember to take their daily Maintenance medicine, 6MP, at home? We are doing...
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NCT06676072
Safety and effectiveness of the TactiFlex SE Catheter and Volt Pulsed Field Ablation (PFA) Generator in subjects with paroxysmal atrial fibrillation
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaThe purpose of the study is to find out if the investigational TactiFlex PFA System, the device that is being studied, is safe and effective in treating adults like you who have atrial fibrillation
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NCT06131372
NN9388-7700: Efficacy and safety of co-administered cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (cagrisema s.c. 2.4 mg/2.4 mg) once-weekly compared to semaglutide, cagrilinitide and placebo in people with chronic kidney disease and type 2 diabetes.
This study is not currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of this study is to see whether CagriSema can lower kidney damage. This will be compared to the effects of semaglutide, cagrilintide and placebo.
Study Duration...
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NCT05845710
Protection against Emboli during caRotid artery stenting using a Neuroguard IEP® Direct 3-in-1 delivery system comprised oF a pOstdilation balloon, integRated eMbolic filter, and A Novel Carotid stEnt III
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaTo evaluate the safety and effectiveness of direct carotid access for stenting using
the Neuroguard IEP Direct System in subjects at high risk for carotid
endarterectomy who require carotid... -
NCT06081894
A PHASE 3, MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF AFICAMTEN COMPARED TO PLACEBO IN ADULTS WITH SYMPTOMATIC NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY Department #: 407-303-7556
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaThe purpose of this study is to compare the effects of aficamten and placebo on health status and exercise capacity in participants with nHCM. The safety and tolerability of aficamten at different...
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NCT06188559
BB-1701-G000-205 An Open-label, Multicenter, Phase 2 Dose Optimization and Expansion Study to Evaluate the Safety and Efficacy of BB-1701, an anti-human epidermal growth factor receptor 2 (anti-HER2) antibody-drug conjugate (ADC), in Previously Treated Subjects with HER2-positive or HER2-low Unresectable or Metastatic Breast Cancer
This study is not currently enrolling.Associated Conditions: Breast CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to determine if a new drug called BB-1701 is safe and effective in people who have HER2-positive or HER2-low, unresectable or metastatic breast cancer (MBC). There are two...
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ACCESS-T1D: Accessing Care, Clinical Trials and Screening for Underserved Children and Adults with Type 1 Diabetes
This study is not currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaACCESS T1D es un estudio patrocinado por AdventHealth y el Departamento de Salud del Estado de Florida que busca personas con riesgo de padecer diabetes tipo 1 (DT1).
El objetivo de este estudio es... -
NCT06313528
TRIPLE G: A Randomized, Double-Blind, Phase 1 Study to Investigate the Effect of LY3437943 versus Placebo on Calorie Intake and Energy Expenditure in Participants with Obesity Under Calorie Restriction
This study is not currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purposes of this study are to look at the effect of the study drug compared to placebo (a drug that looks like the study drug but has no active medicine) on calorie intake...
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NCT05901831
FINE-ONE: A parallel-group, randomized, prospective, interventional, double-blind, multicenter global Phase 3 study to investigate the efficacy and safety of Finerenone versus placebo, in addition to standard of care, in participants with chronic kidney disease and type 1 diabetes
This study is not currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The aim of the study is to demonstrate efficacy of Finerenone when compared to placebo, in addition to standard of care, in delaying the progression of chronic kidney disease (CKD) in...
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NCT05904886
A Phase III, Randomized, Double-Blind, Placebo-Controlled Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMbrave152) (SKYSCRAPER-14)
This study is not currently enrolling.Associated Conditions: Liver CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to compare the effects, good or bad, of tiragolumab plus atezolizumab plus bevacizumab versus placebo plus atezolizumab plus bevacizumab on patients with HCC. In this...